RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
RASAL1
RNA ID
RNA Type
mRNA
Alteration Pattern
methylation
Species
homo sapiens
Detection Methods
qPCR; enzyme-linked immunosorbent assay etc.
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells.
Year
2016
Function
"Hif1 alfa and transforming growth factor (TGF) / smad signaling pathway regulate hypoxia induced endothelial-to-mesenchymal transition (EndMT). through dnmt3a mediated rasal1 promoter hypermethylation and direct snail induction, and participate in the process of myocardial fibrosis."